2022-05220 - Post-Doctoral Research Visit F/M the role of compartmentalization within signaling pathways

Contract type : Fixed-term contract

Level of qualifications required : PhD or equivalent

Fonction : Post-Doctoral Research Visit

About the research centre or Inria department

Located at the heart of the main national research and higher education cluster, member of the Université Paris Saclay, a major actor in the French Investments for the Future Programme (Idex, LabEx, IRT, Equipex) and partner of the main establishments present on the plateau, the centre is particularly active in three major areas: data and knowledge; safety, security and reliability; modelling, simulation and optimisation (with priority given to energy).   

The 450 researchers and engineers from Inria and its partners who work in the research centre's 28 teams, the 60 research support staff members, the high-level equipment at their disposal (image walls, high-performance computing clusters, sensor networks), and the privileged relationships with prestigious industrial partners, all make Inria Saclay Île-de-France a key research centre in the local landscape and one that is oriented towards Europe and the world.

Context

The postdoctoral position is available at EPC MUSCA, a joint project-team between Inria, INRAE and CNRS, gathering members from Inria Centre Saclay–Ile-de-France, INRAE Centre Val-de-Loire (UMR 7247 Physiologie de la Reproduction et des Comportements) and INRAE Centre Ile-de-France Jouy-en-Josas (UR 1404 INRA MaiAGE). MUSCA is an intrinsically interdisciplinary team in Biomathematics and Systems Biology, which brings together applied mathematicians and biologists.
The postdoctoral position is funded by the INRIA exploratory action COMPARTIMENTAGE. The project will be under the supervision of Romain Yvinec, applied mathematician, and in close collaboration with Frédéric Jean-Alphonse, biologist specialised in intracellular signaling, and the team SERPICO, specialised in intracellular imaging analysis.

Assignment

Recent biological imaging have shown that membrane receptors involved in intracellular signaling pathways are capable of inducing cascades of biochemical reactions from extremely dynamic pools of intracellular compartments. The subcellular trafficking of receptors generates spatio-temporal heterogeneous cellular compartments with a critical role on physiological functions, and profound consequences on the search for new therapeutic strategies.
The candidate will develop new modeling formalism, combining biochemical reaction networks and coagulation-fragmentation dynamics to fully represent the diversity and complexity of signaling pathways. By comparing the models with data from confocal microscopy imaging with super spatio-temporal resolution, the candidate will reveal how the spatio-temporal heterogeneity of intracellular compartments conditions the response of cells to extracellular signals.

Main activities

The candidate will design efficient numerical schemes for partial differential equation (PDE) of coagulation type to explore the role of endocytosis, recycling and coagulation-fragmentation dynamics in receptor trafficking, as well the importance of highly dynamics phase transition and coarsening phenomena in downstream second messenger activation.
Using ideas from chemical reaction network theory, the candidate will analyse the long-time behavior of the developed models, according to the underlying reaction network topology and coagulation-fragmentation dynamics, and its consequence for cellular response.

Skills

The successful candidate will have a Ph.D. in applied mathematics, with

  • Strong background in either ODEs, PDEs or stochastic processes.
  • Strong motivation to work in an interdisciplinary team.
  • Interest in chemical reaction network and statistical inverse problems from imaging data.

Benefits package

  • Subsidized meals
  • Partial reimbursement of public transport costs
  • Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)
  • Possibility of teleworking (after 6 months of employment) and flexible organization of working hours
  • Professional equipment available (videoconferencing, loan of computer equipment, etc.)
  • Social, cultural and sports events and activities
  • Access to vocational training
  • Social security coverage

Remuneration

Salary : 2.653 euros gross salary/month